Not the other way around.
The AVATAR™ Cell Control System lets you generate your cells of interest in a microenvironment array and optimize to a growth rate, functional activity or phenotypic change of interest.
Unparalleled microenvironment control:
Modulate culture conditions to cater to your cell type of interest:
Primary Patient Tumor Samples
Precision Microenvironment Control
The AVATAR™ Cell Control System
Why AVATAR is different than anything else out there
Oxygen and pressure have distinct physiological effects and both play important but independent roles in the cellular microenvironment. Under hypoxic and pressurized culturing conditions, changes are seen in cell morphology, gene and protein expression. Modulation of atmospheric pressure affects the mechanobiology of cell function during culture, and has profound effects on cell homeostasis and metabolism.
The human body is made up of diverse microenvironments that influence the behavior and molecular profiles of cells. Tissues are hypoxic and pressurized. They function at a much lower oxygen level than the basic air environment in typical incubator, and interstitial fluid pressures vary depending on the tissue and organ type.
Percent Oxygen by Tissue (% O2)
Interstitial Fluid Pressure by Tissue (PSI)
Greg Semenza’s (John’s Hopkins) important discovery of HIF-1 in cell response to hypoxic environments (Muz et al., Dove Press, 2015, top) was awarded the Lasker Award in 2016 for this major contribution to cancer research. Rakesh Jain (MGH/Harvard), a pioneer in the area of tumor microenvironment (Goel et al., Physiol Rev, 2011, bottom), was awarded the National Medal of Science for his seminal discoveries in tumor biology in 2013.
Fine-tune culture settings to meet your cell’s needs
Modulation of Pressure and Oxygen during culture has profound effects on cell homeostasis
Only AVATAR lets you regulate and alter both the atmospheric pressure and oxygen concentration to what’s optimal for your cell type and research. Promote:
- Cardiomyocyte and neuronal development
- Long-term propagation of primary tumor cells
- Novel target discovery and drug screening
- Efficient transfection and expansion of primary cells
Venn diagram showing the number of induced and repressed transcripts in each RNA-seq transcriptome produced in response to iPSCs exposed to hypoxia, pressure, or both.