You control your cells.

Not the other way around.

The AVATAR™ Cell Control System lets you generate your cells of interest and optimize to a growth rate, functional activity or phenotypic change of interest by providing a microenvironment array that enables fine-tuning of physiological culture conditions.

Unparalleled microenvironment control:
  • Pressure

  • Oxygen

  • CO2

  • Temperature

Fine-tune culture conditions to your cell type of interest:
  • Patient Tumor Samples

  • Immune Cells

  • Stem Cells

Precision Microenvironment Control

The  AVATAR™ Cell Control System

The Human Microenvironment is HYPOXIC & PRESSURIZED

Oxygen and pressure have distinct physiological effects and both play important but independent roles in the human microenvironment. Under hypoxic and pressurized culturing conditions, changes are seen in cell morphology, gene and protein expression. Modulation of atmospheric pressure affects the mechanobiology of cell function during culture, and has profound effects on cell homeostasis and metabolism.

The human body is made up of diverse microenvironments that influence the behavior and molecular profiles of cells. Tissues are hypoxic and pressurized. They function at a much lower oxygen level than the basic air environment in typical CO2 incubator, and interstitial fluid pressures vary depending on the tissue and organ type.

Percent Oxygen by Tissue (% O2)

Interstitial Fluid Pressure by Tissue (PSI)

Greg Semenza’s (John’s Hopkins) important discovery of HIF-1 in cell response to hypoxic environments (Muz et al., Dove Press, 2015, top) was awarded the Lasker Award in 2016 for this major contribution to cancer research. Rakesh Jain (MGH/Harvard), a pioneer in the area of tumor microenvironment (Goel et al., Physiol Rev, 2011, bottom), was awarded the National Medal of Science for his seminal discoveries in tumor biology in 2013.

Fine-tune culture settings to meet your cell’s needs

Customize

Fine-tune key physiological conditions — pressure, O2, CO2 and temp — to tailor phenotype

Replicate

Grow cells consistently every time, and get it done in a shorter window

Accessible

Use your cells with our optimized protocols and xeno-free media for a ready to go solution

Target

Validate specific gene, protein, and metabolic profiles for more accurate assay development

Scale Up

Stack and use multiple AVATARs at the same time for higher throughput

Nurture

Recover cell viability after thawing frozen samples and post-transfection with optimal culture conditions

Modulation of Pressure & Oxygen has profound effects on cell homeostasis

Only AVATAR lets you regulate and alter both the atmospheric pressure and oxygen concentration to what’s optimal for your cell type and research. Promote:

  • Novel target discovery and drug screening
  • Expansion of primary cells
  • Mimic the immune-suppressive tumor microenvironment
  • Long-term propagation of patient tumor cells
  • Macrophage generation
  • iPSC generation
  • Neuronal differentiation
  • Cardiomyocyte maturation

Venn diagram showing the number of induced and repressed transcripts in each RNA-seq transcriptome produced in response to iPSCs exposed to hypoxia, pressure, or both.

See how the AVATAR can improve your cell therapy…

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