avatar FOUNDRY™
Automated cGMP Manufacturing
The AVATAR Foundry is a closed system for the production of autologous cell therapies designed to accelerate cell therapy development from early-stage research through cGMP production. By providing precise, independent control of oxygen, pressure, and CO₂, the Foundry enables users to replicate critical aspects of the in vivo tumor microenvironment, yielding therapeutic cells with enhanced potency, persistence, and metabolic fitness.
KEY FEATURES
Enhanced Potency Through Metabolic Priming
Utilizes Hyperbaric Pressure Control and precise Oxygen Regulation to mimic the native Tumor Microenvironment (TME). This "trains" cells to resist suppression and drives superior potency and long-term persistence.
Unmatched Scalability and High-Yield Production
Features the proprietary XPANDR Cell Culture Bags that automatically scale volume within a single run. The gas-permeable design maximizes cell expansion without sacrificing product quality or needing manual transfers.
Automated, cGMP-Compliant Manufacturing
A fully enclosed, hands-off system designed for regulatory compliance. Automation minimizes variability, reduces manual touchpoints, and ensures seamless scale-up from process development to clinical production.
Seamless R&D-to-Clinical Transferability
Maintain optimal culture conditions from benchtop R&D to clinical manufacturing for effortless technical transfer and consistent cell quality. This continuity reduces process variability and accelerates your path from early discovery to clinical deployment.
One-Touch Automated Liquid Handling and Sampling
Integrated, closed-loop liquid handling allows for automated feeding, product sampling, and harvest at the push of a button. This reduces labor costs and contamination risk, ensuring precise nutrient exchange to maximize cell viability and yield.
Seamless Integration with Upstream Processes
Designed for simplified aseptic connection to standard cell processing devices. The compact, modular design facilitates easy placement and integration into existing cleanrooms and manufacturing suites.
TECHNICAL SPECIFICATIONs
Physical
Width | 706 mm (27.8") |
Depth | 740 mm (29.1") |
Height | 740 mm (29.1") |
Weight | 140 kg (308.6 lbs) |
Environmental Operational Ranges
Oxygen | 0.1 - 16.9% |
Carbon dioxide | 0.5 - 10.0% |
Temperature | 25.0 - 40.0 °C |
Pressure | 0.0 - 7.0 PSI |
Humidity | > 90% RH |
Process and Fluid Handling
Minimum loading volume | 50 mL |
Maximum harvest volume | 1.5 mL |
Tubing compatibility | PVC tubing compatible with Genesis Rapidweld II, Terumo TSCD-II tube welders |
Sampling method | Syring sampling through clave port; Rocker used for cell resuspension |
Pump speed | 5 - 50 mL/min |
Agitation | Up to +/- 30° rocking along axis |
Interface and Software
Software | OPC Unified Architecture (UA)-compatible |
Touchscreen | 12.1" display |
The Foundry Advantage:
Enhanced Potency and Persistence
Metabolic Reprogramming Yields Optimal Phenotype
Conventional
CAR T cells
AVATAR
CAR T cells
Metabolic programming enabled by the Foundry's controlled environment drives the selective expansion of central memory and stem-like T cells (Tcm/Tscm). This results in a superior product phenotype, correlating directly with enhanced persistence and clinical efficacy.
Persistent Killing Over Repeated Tumor Challenges
Conventional CAR T cells
AVATAR CAR T cells
Challenge 1
Challenge 2
Challenge 3
Challenge 4
Challenge 5
CAR T cells manufactured in the Foundry exhibit persistent cytotoxic activity over repeated tumor challenges without exhaustion. Unlike conventionally manufactured cells that show diminished killing capacity after multiple tumor encounters, these optimized CAR T cells maintain robust cytotoxic responses for durable clinical outcomes.
Sustained Tumor Killing, Even at Low E:T Ratios
Conventional CAR T cells
AVATAR CAR T cells
1:27
1:81
1:243
E:T Ratio
CAR T cells expanded in the Foundry maintain strong cytotoxic function at low effector-to-target ratios that mirror the tumor microenvironment where limiting numbers of T cells must persistently kill tumor cells without exhaustion.
TRUSTED BY GLOBAL LEADERS IN CELL THERAPY MANUFACTURING
