FROM RESEARCH SCALE TO CLINICAL SCALE AVATAR HAS YOU COVERED
The AVATAR Odyssey stands apart from other cell culture systems. Using precise control of hyperbaric pressure and oxygen levels, therapeutic immune cells are rewired with:
improved potency and persistence
increased expansion
higher transduction efficiency
The AVATAR product family uses the HYPERPRESS incubation technology, allowing for direct transfer from process development to GMP manufacturing
2X More Potent Cells
Persistent cytotoxicity at 1:16 Effector:Target ratios observed in AVATAR expanded cells
Hyperbaric pressure and precise oxygen regulation provide optimal manufacturing conditions for producing potent & persistent therapeutic cells.
2X Increased Cell Expansion
Significant increase
in CAR T expansion observed in AVATAR
By growing cells under an optimized environment, the AVATAR Odyssey increases the expansion of challenging patient-derived cells.
30% Increased Transduction
Significant increase
in CAR+ cell percentage when expanded in AVATAR
Viral transduction under pressurized culture conditions increases efficiency, lowering vector cost and enhancing potency.
2X Enhanced Immunometabolism
Persistent cytotoxicity at 1:16 Effector:Target ratios observed in AVATAR expanded cells
GLUT1 is associated with improved potency in solid tumor microenvironments and is significantly upregulated in CAR T cells expanded with the AVATAR Odyssey.
model the tumor microenvironment with
the avatar odyssey
Only AVATAR Odyssey lets you regulate and alter both the atmospheric pressure and oxygen concentration to what’s optimal for your cell type and research
Modulation of pressure & oxygen has profound effects on cell homeostasis
Oxygen and pressure have distinct physiological effects and both play important but independent roles in the human microenvironment. Under hypoxic and pressurized culturing conditions, changes are seen in cell morphology, gene and protein expression. Modulation of atmospheric pressure affects the mechanobiology of cell function during culture, and has profound effects on cell homeostasis and metabolism
Study how cells respond under physiological culture conditions
Cells under pressure: The AVATAR Odyssey can regulate pressure settings to alter gene and protein expression profiles of cells
Users all over the world have adopted the AVATAR Odyssey
AVATAR
odyssey
tumor environment modeling
Identify novel checkpoint inhibitors that work effectively under immunosuppressive tumor microenvironments
stem cell differentiation
Enhance iPSC reprogramming & stem cell differentiation efficiency
cell therapy optimization
Enhance CAR-T potency, persistence & homing
organoid research
Generate organoids and spheroids that thrive under hypoxic culture conditions